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KMID : 0379520020180020167
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한국독성학회지
2002 Volume.18 No. 2 p.167 ~ p.174
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Background Data for Fertility and Early Embryonic Development Study in Sprague-Dawley Rats
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Kim Jong-Choon
Lee Sang-Joon
Suh Jeong-Eun
Cha Shin-Woo
Kim Choong-Yong
Han Jeong-Hee
Chung Moon-Koo
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Abstract
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Historical control data have been shown to be valuable in the proper interpretation and validation of reproductive toxicology studies. The present data were compiled from rat fertility and early embryonic development studies conducted at Korea Institute of Toxicology during the 1994∼2001 period. These data were assembled in order to provide background information for the general and reproductive data collected in 11 fertility and early embryonic development studies using Sprague-Dawley rats obtain-ing from the Breeding Facility, Korea Institute of Toxicology, Korea. A total of 274 males and 274 females were used in these studies during the eight-year period. Parameters of fertility and early embryonic development included clinical sign, body weights, food consumption, organ weights, estrus cycle, copulation index, precoital time, fertility index, pregnancy index, sperm parameters, and early embryonic development parameters. Most of the values were comparable to the previous historical control data reported by other investigators. These data can be wed not only as a historical data base for the meaningful interpretation of data from reproductive and developmental toxicity studies, but also as a contribution to biological characterization of Sprague-Dawley rats.
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KEYWORD
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Historical control data, fertility, Embryonic development, Rodent
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